Steve HOLMES
Co-Founder and CEO,
Cholangiocarcinoma Foundation Australia
Late-stage IV cholangiocarcinoma survivor
I keep cancer patients’ options open.
The Cure We Seek Is In The Cause
My work is in cancer biology, specifically bile composition and flow, and the biliary ductal system that carries it.
We reverse-engineer failure points in both the bile and the cells that line the ducts, then track that back to each root cause.
That is where we see prevention and curative response options.
We then scale that knowledge.
A Silent Threat On The Increase.
Think of the biliary system as your body’s biological engine, and bile as the engine oil keeping all the parts working properly.
In a healthy system, the liver makes the oil, the gallbladder stores it, and the ducts transport it to the gut to facilitate essential nutrient delivery.
But if that oil becomes thick, sludgy, and toxic, it corrodes the ducts and blocks the flow to the gut.
Suddenly, the body faces two catastrophic problems:
1. Constant structural damage to the cell membranes from a slow-moving, corrosive, toxic bile.
2. Starvation of life-support lines: vital nutrient delivery is restricted or stopped to cells already under intense pressure to defend themselves against the bile.
That combination escalates cell failure.
If those conditions continue, the damage begins to outpace the immune system’s capacity to repair it, and cancer can form.
And what’s more… this all happens in silence. You, the driver of this engine, remain unaware until it breaks.
By mapping exactly what turns the bile composition and flow toxic, and where cells fail, we pinpoint precisely where the healthy sequence breaks. We see the failure at the source, and focus there.
We Built A Foundation To Operationalise It
A patient-led foundation with two clear objectives rooted in this exact science:
1. Help today’s patient survive now, not default to future promises.
2. Help today’s families understand the cause now, so they do not become tomorrow’s newly diagnosed patients.
Our foundational model is built on survival execution, not advocacy and awareness.
Claire and I believe that people will always advocate for what actually works, and that drives awareness on its own.
So that is why we focus entirely on what must be done for today’s patient survival today, and the prevention of tomorrow’s.
That was a very tough line in the sand for a patient and caregiver to draw.
But it was exactly what was missing in this fight.
So we decided to be absolute about it.
Today’s survival and tomorrow’s prevention are what we execute, now.