Steve shares his knowledge, experience, and wisdom to help better equip and empower your capacity to mount a robust and effective response to a serious challenge.

steveHOLMES

2 brothers diagnosed with the same aggressive terminal cancer and 6 months to live. 

“Steve survived, but Graeme did not. Steve’s survival became a modern-day medical breakthrough that provided a new doorway to how patients can better respond and survive a serious cancer diagnosis.”

Surviving stage 4 metastatic and terminal cancer is remarkable in itself, it attracts attention, and therein lays a new unexpected responsibility.

Cancer patients suffer a lot, that’s what it is to be a patient, so anything that I can do to alleviate that suffering is a good thing, a positive thing, a meaningful thing. Sharing my story, knowledge, experiences, and wisdom in the best way possible does exactly that, it helps make other patient’s lives more liveable and shines a light on what is possible.

cancer READY

I find a lot of patient suffering comes from not understanding things and the confusion and overwhelm that comes from that. So helping people understand their diagnosis and options is a good start to improving their survival chances.

I have also learned the advantages of becoming cancer-ready, just as CPR awareness and basic knowledge can improve survival rates.

steveHOLMES

2 brothers diagnosed with the same aggressive terminal cancer and 6 months to live. 

“Steve survived, but Graeme did not. Steve’s survival became part of a modern-day medical breakthrough, providing a new pathway for how patients can better respond to and survive a serious cancer diagnosis.”

Surviving stage 4 metastatic and terminal cancer is remarkable in itself, it attracts attention, and therein lays a new unexpected responsibility.

Cancer patients suffer a lot, that’s what it is to be a patient, so anything that I can do to alleviate that suffering is a good thing, a positive thing, a meaningful thing. Sharing my story, knowledge, experiences, and wisdom in the best way possible does exactly that, it helps make other patient’s lives more liveable and shines a light on what is possible.

cancerREADY

I find a lot of patient suffering comes from not understanding things and the confusion and overwhelm that comes from that. So helping people understand their diagnosis and options is a good start to improving their survival chances.

I have also learned the advantages of becoming cancer-ready, just as CPR awareness and basic knowledge can improve survival rates.

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MY VIDEO STORY

Part 1 | Part 2

14,000 km’s

All Done and Dusted 14,000 km’s

I cycled the equivalent of Australia’s coastline—14,000 km—to raise funds for two vital causes: delivering Free Patient Navigator Journals and advancing research into early detection methods for bile duct and bile-related cancers such as liver, gallbladder and pancreatic.

The 13-month journey was grueling, with storms, torrential rain, oppressive humidity, and relentless afternoon winds testing my resolve. But this challenge, like my fight against cancer, demanded more than grit—it called for me to once again unleash that unbreakable inner will.

The secret? Once again – Persistence and Perseverance became my magic combination – easily said but in reality bloody hard to do consistently. I think discipline reinforces habit which builds discipline, after that its a matter of, don’t think about the challenge – just ride!

To everyone who supported this mission, thank you. Your generosity has created life-saving resources that actually reach the coalface of today’s patient battle.

Why Ride So Far

Why cycling, and why so far? Before cancer, cycling was my escape—it kept me fit and, I believed, healthy. Yet here I am, back in the ICU at Gold Coast University Hospital for the second time in six weeks. I had lost a significant amount of blood and had just survived emergency surgery for a major aneurysm in my liver’s main hepatic artery. I felt weak—far weaker than I ever imagined a person could be.

The nurse assigned to my bed greeted me gently: “Hello Stephen, it’s good to see you back with us.” She explained where I was and how close I had come to dying—mere minutes, if not seconds. “You’re lucky to still be here,” she said. At first, I wasn’t sure if I was awake or dreaming. Slowly, everything came into focus, and I began to remember the events leading up to the aneurysm. Yes, I was lucky.

Knowing my passion for cycling, the nurse positioned the TV over my bed. The Australian Women’s Road Race in South Australia flickered on the screen, and she left me to tend to her duties. I smiled—what timing, I knew one of the riders favoured to take out the title, and, almost instinctively, my sense of competitiveness stirred.

As I watched the cyclists power uphill, a thought struck me: I might never ride again. I related to how they dug deep, stretching the gap on those falling behind, and I could almost feel that familiar burn—the deep pain in a cyclist’s legs on any tough climb. I remember thinking, I would trade the pain of cancer for that deep-burning leg pain in a heartbeat. Strange as it may sound, to once again experience that pain would mean proof of life.

Cycling isn’t something typically achievable for someone who has lost multiple organs and faced a cancer that is rarely beaten—although scared, I wasn’t willing to let that stop me.

Having survived late-stage, stage 4 cancer, it took me nearly two years of effort and determination to reclaim enough confidence and fitness to cycle faster than a parked car going in the opposite direction.

There’s no manual for this kind of thing. But with significant help from an old cycling mate, Kev—who showed up most days to tow me along until I could once again ride a respectable distance on my own—the day finally came when I could set myself a new challenge. It had to be bigger than anything I had ever done before—something that would stretch my mind and inspire others like me to see what is possible.

As a patient, one of the most powerful sources of strength is seeing a patient like yourself rise above their challenge. It lifts your spirits, fuels your effort, and rekindles that innate belief in what is possible. It motivates you to take the next step—or pedal stroke, in my case. Ride Within, Ride With Rhythm, Ride for Tomorrow was the tune I tapped out in my mind as I carved out hundreds, then thousands, of kilometres.

These journals are a critical lifeline for those facing highly lethal bile-related cancers—such as liver, bile duct, gallbladder, and pancreatic cancers—all of which carry devastatingly poor survival outcomes.

For these patients, there are no options for early detection, no curative treatments, and no meaningful life-extending therapies outside of surgery—and even then, only a small subset qualify. With overall survival rates below 10%, and just 2% for those diagnosed with metastatic disease—which sadly represents the majority—these diagnoses often leave patients feeling like there’s no way forward.

Having lived through and survived this devastating reality myself, Claire and I knew we had to act quickly, as these diseases are surging alarmingly in younger people. Over the past decade, bile-related cancers have increased by an average of 60%, now affecting a growing number of individuals in their 30s and 40s—yet there has been no meaningful progress in improving survival outcomes for this train wreck of a cancer.

Together, we turned my personal success into action, developing the Patient Navigator Journals to provide a much-needed starting point—a bridge between having no options and discovering a possible pathway to survival.

These journals are designed to better equip and empower patients to understand and more effectively respond from the moment of their diagnosis

More importantly, cycling isn’t something typically achievable by someone who has had multiple organs removed and faced a cancer that is rarely beaten. Having survived late-stage, stage 4 cancer, it took me several years to reclaim the confidence and fitness to cycle faster than a parked car going in the opposite direction. But the day finally came when I could set such a challenge—and inspire others like me to see what is possible. There is no manual for this kind of stuff.

As a patient, one of the most powerful sources of strength is seeing someone like you rise above the pain of dying. It lifts your spirits, fuels your effort, and rekindles that innate belief in what is possible. It motivates you to take the next step—or pedal stroke, in my case. Ride Within, Ride With Rhythm, Ride to Tomorrow was the tune I tapped out in my mind as I carved out hundreds, then thousands, of kilometres.

These journals are a critical lifeline for those facing highly lethal bile-related cancers—such as liver, bile duct, gallbladder, and pancreatic cancers—all of which carry devastatingly poor survival outcomes.

For these patients, there are no options for early detection, no curative treatments, and no meaningful life-extending therapies outside of surgery—and even then, only a small subset qualify. With overall survival rates below 10% and just 2.5% for those diagnosed with metastatic disease—which sadly represents the majority—these diagnoses often leave patients feeling like there’s no way forward.

Having lived through and survived this devastating reality myself, Claire and I knew we had to act quickly, as these diseases are surging alarmingly in younger people. Over the past decade, bile-related cancers have increased by an average of 60%, now affecting a growing number of individuals in their 30s and 40s—yet there has been no meaningful progress in improving survival outcomes for this train wreck of a cancer.

Together, we turned my success into a clear pathway of steps and actions, developing the Patient Navigator Journals to provide a much-needed starting point—a bridge between having no options and discovering a possible pathway to survival.

We desperately need funding for more Patient Navigator Journals as we head into the Christmas season – please help if you can. These journals are designed to better equip and empower patients to understand, engage, and more effectively respond from the moment of their diagnosis.

“I cannot speak highly enough of the Patient Navigator Journal. I owe so much to the Cholangiocarcinoma Foundation Australia. The information and support I received were life-changing. When I experienced a recurrence, I knew exactly what steps to take because of the tools and knowledge Steve provided. Please support Cholangiocarcinoma Foundation Australia’s patient initiatives—I certainly do!”
Lynette Williams, Patient Survivor

Be Bold Lean Into It

Hope: A Tangible Path We Construct

Hope isn’t a gift we wait for—it’s something we unlock. It rises from our inner will to overcome the very obstacles that block our path, forming a vision and creating a way forward.

When life confronts us with seemingly insurmountable challenges, like a terminal cancer diagnosis, it ignites our unbreakable will, fueling hope and lighting the way when all known paths and options have been exhausted. Hope becomes our inner bridge between the impossible and the possible. By giving hope oxygen, we breathe life into it, turning possibilities into realities—our reality.

Granted, this may not be your everyday way of thinking, but when faced with the gravity of terminal cancer and the prediction of imminent death, your perspective undergoes a seismic shift. You begin to see things you couldn’t before, things that others cannot see.

Yet, for those not compelled by such absolute necessity, they cannot see your path—they only see the hopelessness of the impossible. But that was okay; they weren’t the ones building it. Claire and I were. Hope doesn’t rely on the agreement or guarantees of others; it thrives despite them, guiding us one step at a time, despite the noise. The lesson learned is that seeking guarantees and promises from those unaffected, skilled, or lacking in lived experience is, in fact, a cancer in itself, further weakening our ability to respond.

When facing a serious cancer diagnosis, bold deliberation, persistent creativity, and unwavering perseverance—born of our inner will—become our bridge-building tools. They help us cut through the noise of misguided opinions and cultivate the endurance needed to flip cancer on its head and break its grip. We move forward not because the way is certain, but because we know it is the only way.

Become a straightforward thinker:
If the path is blocked, go around. If the fruit is bitter, throw it out. Sometimes, the longest way home is the quickest way home.

Simple! Yet Not Easy

But this is how we see the possibilities we didn’t see before. By remaining open to such thinking, we leave a light on, ensuring that opportunity will always have a way to find us—even in the darkest of moments.

Many times hope was the only strategy I had left.
I instinctively knew that if I did not lean into this, it would lean back even harder.

Nature, to be commanded, must first be obeyed.”Francis Bacon
“Therefore To control and defeat this cancer, I would also need to understand it.”Steve H.

My Story

When I was 29, my dad, just 52, was coaching my brother Graeme and me at cricket practice. Graeme and I were in the practice nets for batting practice and Dad was retrieving the balls and returning them back to the bowlers when Dad collapsed—a heart attack. I didn’t know how to perform CPR. I stood there, helpless, as he died right in front of us. I have carried that guilt for years.

Years later, my younger brother called me with devastating news: he had cholangiocarcinoma, a rare and aggressive bile duct cancer. He was terrified—very terrified. Once again, I was overwhelmed by that same helplessness. I could do nothing, and he passed away. I was his older brother—someone he looked up to and I could not help.

Two years later, I was diagnosed with the exact same cancer as Graeme. Despite being in a worse condition, I somehow survived. My mum wanted me to walk away from it all and move on with my life. She had already lost her husband and one son; she couldn’t bear the thought of losing me too. I understood her plea, but I couldn’t walk away. My brother had children, and I had two of my own. It was in the collision of all these thoughts that I realised my survival had become more than a personal victory—it was an unexpected responsibility and an opportunity to become part of the solution.

I now had an incredible opportunity to ensure, as best I could, that I would never again be paralysed by helplessness. I could break this cycle—I could become better prepared and play an integral role in the cancer success equation.

Each of us has the same opportunity: to do our best. That is all anyone can do or be expected to do—our best, nothing more, nothing less. And that’s exactly what I needed to focus on.

I had survived, and in doing so, gained uniquely valuable insight into defeating a high-lethality cancer. Through the obstacle of this disease and my journey through it, new possibilities emerged—possibilities that only I, as a patient deeply immersed in the fight for survival, could truly see and understand. My success had not only become part of the solution but had also underscored a profound responsibility that came with it.

A responsibility to develop the skills needed to effectively share these hard-earned insights and to build upon them—to bridge the gaps and address the unmet needs that both Claire and I had observed in medical science and the delivery of best practices. These possibilities demanded attention—my attention!

Driven by pure necessity, I realised it would be up to me to ignite the momentum needed to galvanise those of talent and great character—the two essential, interdependent components required to embrace this effort and elevate it to its higher reality. I would have to persevere until momentum itself reached out and embraced my efforts—until the inherent value within this bold and audacious challenge rose above the noise and was embraced by science, healthcare, and ultimately today’s patients.

Yes, an audacious and bold challenge undertaken by a mere patient. But it was my responsibility to carry this philosophy and its possibilities from the battlefields of cancer that I had just come from—battles where resilience and survival are forged—to the classrooms of understanding, the laboratories of innovation, and the bedsides of patients. Separating these battlefield lessons from the emotions that carried them seemed logical at first, but I came to realise those emotions were an essential part of the lessons themselves. They gave meaning and power to the insights I had gained.

This was becoming a journey driven by pure necessity, shaped by hard-earned lived experiences and the laser-focused purpose they brought—purpose and perseverance that demanded I adapt and evolve at every step. It became a journey of critical thinking, never allowing assumptions to lead but instead steadily transforming chaos into its counterpart: clear, purposeful steps—a pathway that broke down the overwhelming challenge of cancer, where each step seamlessly followed the next until survival was within reach.

Now, as you read this, perhaps you understand why I do what I do. You don’t need to be a doctor or a scientist to make a difference, anyone of purpose and resilience can rise above what stands in the way. Just imagine if doctors, scientists, politicians, and others with talent and great character carried this same thinking into everything they do! Talent is common place – great character is not, together they are magic!

We each get one life—one chance. Most people don’t see that the real opportunity is life itself: to do and leave your best, nothing more. Life’s pathway is built from obstacles and the possibilities within each – our opportunity to shape the path that others benefit from.

That’s how we create change: by leading by example until others see the value in what we do. That’s how we give our best. That’s how we leave a legacy that adds value beyond ourselves and our time.

From healthy cyclist to terminal cancer patient with weeks if not days to live, then back to cycling 400kms per week, and pioneering a new patient-led era in cancer response.

One moment I was a fit and healthy cyclist, the next, I was battling an aggressive and terminal cancer with an unbeaten record. Like most people, I was naive if not blissfully ignorant to the fact that healthy people can also get cancer. Health and fitness as I was to learn are very subjective and widely open to interpretation.

Late October 2016: Symptoms

It was a regular Saturday morning coffee ride between Main Beach and Burleigh on the Gold Coast when I experienced a sudden onset of weakness, much like a bad flu coming on. I had to abandon the ride and head straight home to the couch. Little did I suspect that this would mark the beginning of a battle for my life.

November 2016: The Diagnosis

Diagnosis – Prognosis: I was diagnosed with cholangiocarcinoma and a prognosis of 6 months, the exact same diagnosis that had claimed my younger brother Graeme just two years earlier.

December 8th 2016

Whipple Surgery: The Whipple is a multi-organ surgery performed by a team of 7 surgeons over 14 hours. It/they removed a shopping list of my vital organs: 95% bile duct, gallbladder, 80% stomach, head of the pancreas, and 100% duodenum (Small Colon).

January 5th, 2017

An emergency aneurysm in my main hepatic artery nearly claimed my life. With only minutes to spare, thanks to an amazing surgical save by Dr. Tom Snow—who only moments before was in his car about to leave the hospital—I survived. Without his intervention, I wouldn’t be here to tell this tale.

July 2017: Aggressive Recurrence

The cancer returned aggressively. Now with weeks if not days to live, my oncologist, Dr. Matthew Burge, threw me a highly speculative ‘Hail Mary Pass’ in the form of a phase 2 clinical trial that had no success record with cholangiocarcinoma or pancreatic cancer at that time.

Too weak to sign the contract unassisted, Claire held my arm up while Matt guided the pen in my hand so I could sign the trial contract. Immediately after I signed, Matt looked me straight in the eye and, with his best cycling voice, said, “Steve, you have one job —stay alive for the next 30 days.” That was how long I would have to wait to receive my first infusion.

The Hail Mary: This new concept in enlisting our immune system to eliminate cancer, developed by Professors James Allison and Tasuku Honjo, would later win them a Nobel Prize in 2018.

August 8, 2017: The Hail Mary Pass is Thrown

Day 1: I made it to my first infusion.

August 11, 2017: Catching the Hail Mary

Day 3 Post Infusion: Miraculously, just three days later, I caught Matt’s pass and scored a touchdown: all my pain disappeared, and I could sit up, breathe freely, and walk normally.

October 2017: A Historic Milestone

Nine weeks later, scans confirmed I was completely NED (No Evidence of Disease), the first-ever cholangiocarcinoma patient to dynamically reverse a stage 4 cancer from such a late-stage setting. It was a special moment in anyone’s life. You can read more about that below.

A New Path and an Unexpected Responsibility

This whole experience set me on a new course, combining my pre-cancer life experience with the expertise gained in overcoming an unbeatable diagnosis. I had risen above what I thought I was capable of achieving, both physically and mentally. Driven to survive, I had forged a new pathway between the unlikely and the impossible. It was said to me, “Steve, you have walked and lived the hypotheses of the greatest minds in cancer science today, something that few can claim.” This incredibly unique lived experience revealed an unexpected responsibility.

I had to boldly and creatively leverage my unique advantage and pioneer a new patient-led response to cancer. This response pathway—a mix of process and culture—ensured that today’s science would be more fully understood and utilized to benefit today’s patients battling to survive. I aimed to bring science and healthcare around the empowered patient, thereby forging new shared pathways in how we approach and respond to cancer. This strategy increased effective engagement and capabilities at all levels, materially boosting five-year survival rates and beyond.

Cycling: Survival and Transformation

As it transpired, my passion for cycling carved out a path through decisions and connections that ultimately saved my life. Cycling became not only my distraction but also my connecting interest with many who had a hand in keeping me alive. It continues to influence how I live life, think, and act on those thoughts. Cycling has become an amazing introspective filtering and transformational space.

Video: Part One of Two

Graeme and Steve Holmes

Two brothers same aggressive terminal cancer and 6 months to live.

Symptoms

While cycling I suffered a sudden loss of energy, much like the onset of a bad flu. The next day these following symptoms became obvious:

  • Increasing lethargy
  • Yellowing eyes
  • Itching and yellowing hands
  • Pale-clay-colored stools and dark urine
Cancer Diagnosis Details
Surgeries ( total:25 hours)

Whipple Multi-Organ Removal

Surgical Complications
Clinical Trials
Attica:

Attica trial is trialing an adjuvant therapy.

  • 6-month Chemo, weekly infusions (12 hr days) not well tolerated
  •  2 year follow up
  • At 5.5 months, I experienced a prolific metastatic breakout
  • Mets Description: Large multiple tumors under my right rib cage, across the top of my liver, and both lungs – (too many to count.) Breathing became labored with every breath, and sitting became increasingly difficult.
  • Now – late-stage, Stage 4 Prognosis: weeks to days without further intervention
Keynote 158 (Aug 2017): Monoclonal Immunotherapy
Hail-Mary PassPass of Last Resort

  1. 3 weekly infusions
  2. Response – Day 3
  3. Cytokine Release Syndrome– CRS Level > 3+: Day 4 to Day 12
  4. Complete & Full & Response – officiated at 9 Week Scan
  5. Reference: NED – Remission – Cure
Biomarkers

(For distribution)

About Steve Holmes

Steve spearheads efforts to tackle bile duct & bile-related cancers, pioneering the concept that “Bile Health & Effective Patient Response Matters.”

Guiding Principle:

Simplification
➡ Increases Understanding
➡ Which Increases Engagement
➡ Which Enhances Effective Response
➡ Which Improves Survival Outcomes

His Focus: Implementing Effective Response Strategies and Processes to Increase Survivorship, and Prevention and Early Detection to Reduce Incidence Through a Four-Fold Approach.

1️⃣ Patient Response Strategies and Processes: Innovating and implementing to better Equip and empower patients to more effectively, understand, engage and respond from the moment of their diagnosis.

2️⃣ NGS Integration: Ensure Molecular (Genomic Profiling) Next-Generation Sequencing is clearly understood by the patient and established as a fundamental part of response strategies, expanding clinical trial access, treatment options, and driving survivorship breakthroughs.

3️⃣ Root Cause Research: Analyse toxic bile conditions as the root cause of bile duct and related cancers to advance prevention and early detection methodologies, reduce the incidence, and identify cancer before it forms.

4️⃣ Building Effective Communities: Establish separate, constructive communities within sciences, pharma, clinical practices, patients, & advocacy, then integrate their efforts to collaboratively address the challenges of cancer.

This approach is vital given the alarming rise in younger patients, requiring support communities built on lived experience, talent, & great character—all deeply interconnected.

Patient-Led Response

In 2018, Steve co-founded the Cholangiocarcinoma Foundation Australia with Claire—a uniquely patient-led cancer research & advocacy initiative ensuring today’s medical research, advancements, & educational innovations directly benefit today’s patients, today.

With no early detection, no meaningful life-extending treatment options, & no curative options beyond surgery—benefiting just 15% of patients, 85% of whom recur—survivorship is further diminished as incidence continues to rise. A new approach was urgently needed.

A rare survivor of late-stage IV cholangiocarcinoma, Steve endured lengthy, invasive surgeries & survived an emergency mercy dash due to uncontrolled blood loss from a main hepatic artery aneurysm—a remarkable surgical save with seconds to spare. Despite this, the cancer returned aggressively; with all traditional options exhausted, a speculative clinical trial emerged.

Steve attributes his survival to his calm & composed wife, Claire, alongside people with the rare combination of experience, talent, & great character, enabling him to survive long enough to participate in groundbreaking, newly emerging immunotherapy advancements made possible by Next-Generation Sequencing.
More: steveholmes.net.au

Research & Collaborations

» Advancing clinical trial & treatment options & access.
» Controversies of Biliary Tract Cancer Management.
» 2025 CCF (USA) Conference – Global research initiative by ICRN & ENS-CCA Precision-BTC-Network.
» Author: Understanding Bile Duct & Bile-Related Cancers.
» Author: Cancer Chronicles: The Patient GI Compass – Simplifying Complexities to Increase Understanding, Engagement, & Effective Response.

Revolutionising Response to Cancer

Steve is leading a global push into bile health research, pioneering the concept that “Bile Health Matters” and identifying toxic bile as the primary trigger of bile duct cancer and other bile-related cancers, including those of the liver, gallbladder, pancreas, and duodenum.

His extraordinary survival from late-stage, stage IV bile duct cancer (cholangiocarcinoma)—a highly aggressive cancer with a metastatic survival rate of just 2%—is a testament to his resilience, determination, and visionary leadership.

Steve’s journey involved surviving 25 hours of life-threatening surgeries to remove multiple organs, including his bile ducts, gallbladder, stomach, pancreas, and duodenum. He also survived a near-fatal aneurysm with just minutes to spare and endured the devastating loss of his younger brother, Graeme, to the same diagnosis.

These profoundly impactful experiences uniquely positioned Steve to tackle critical challenges: the total absence of early detection methods, no curative treatments outside of a slender subset who qualify for surgery, the complete absence of meaningful life-extending therapies, and an alarming 60% rise in bile-related cancers over the past decade, increasingly affecting younger patients in their 30s and 40s.

Optimal Patient Response Initiative (OPR)

In response, Steve developed the ‘Optimal Patient Response Initiative’ (OPR), a groundbreaking approach that shifts the focus from passive care to proactive patient response, a key component almost always overlooked.

OPR harnesses the unique expertise and experiences of both patients and medical professionals who specialise in this diagnosis. It captures the lived experience and invaluable expertise of patients and caregivers, empowering them to identify the right medical professionals for their diagnosis from the outset, ask the right questions, and follow a carefully crafted pathway of steps. Similarly, medical professionals with specific expertise and high-flow experience in these cancers contribute advanced clinical insights and specialised knowledge. OPR integrates these critical and complementary components, creating a unified pathway for effective collaboration.

By doing so, OPR transitions patients and caregivers from passive passengers to informed co-pilots, equipping them to engage, understand, and respond more effectively. This dynamic collaboration fosters a culture of innovation and possibility, essential to improving outcomes in this specific group of high-lethality cancers.

While OPR focuses on improving survival statistics for diagnosed patients, bile composition research works to reverse the alarming rise in incidence rates—potentially halting cancer before it forms.

Toxic Bile Triggers Cancer

Steve emphasises that toxic bile is a primary driver of bile duct and related cancers. In the low-oxygen, low-blood-supply environments of bile and pancreatic ducts, cells are naturally predisposed to glycolysis—a metabolic process where cells produce energy from glucose (sugar), often described as a hallmark of cancer cell survival. This adaptation enables cells to generate energy even in oxygen-deficient conditions, which becomes particularly advantageous when cells are damaged and no longer functioning normally.

When cells are damaged, this predisposition enhances their transition into a dysregulated state, where glycolysis becomes the dominant metabolic pathway. This shift supports uncontrolled cell growth and survival, laying the foundation for cancer development.

This predisposition, combined with the damage and injury caused by the chronic abrasive forces of toxic bile on the delicate epithelial protective lining, acts as a spark in an already volatile environment. In this state, damaged cells are able to transition more rapidly into a dominant glycolytic metabolic state—a state highly conducive to cancer progression.

Steve highlights that knowing and maintaining healthy bile composition is critical to preserving the integrity of the bile ducts’ delicate protective lining, where these cancers originate. By preventing injury to this lining, the progression toward cancer can be averted. As Steve succinctly puts it: “Healthy bile, healthy bile ducts, no cancer.”

Cholangiocarcinoma Foundation Australia

Steve co-founded the Cholangiocarcinoma Foundation Australia with his wife and caregiver, Claire. This patient-led cancer research and advocacy initiative ensures that today’s innovative research and technology directly benefit today’s patient survival outcomes.

Recognising the urgency of these challenges, Steve co-founded the Cholangiocarcinoma Foundation Australia with his wife and caregiver, Claire. This patient-led cancer research and advocacy initiative ensures that today’s innovative medical research and technology directly benefit today’s patient survival outcomes. By supporting and funding projects, the foundation more effectively influences and improves survival outcomes, helps make the lives of patients and their families more manageable, and continue shining a light on what is possible.

“Because a thing seems difficult, do not think it impossible.” – Marcus Aurelius
“There is always a way if we can remain open to such thinking.” – Steve H.

Why Cycling?

Because I Can – Cancer took it from me, but I have taken it back. Cycling like life requires the disciplines of ‘persistence’ and ‘perseverance’, it grounds my effort and keeps me connected to the opportunity—life.

ICU hospital beds sparked the initial motivation, cycling offered a parallel world to distract me from the thoughts of dying, and then later on it physically became my special place of introspection, vision, and a transformative workshop on wheels to expand on what I had learned.

The future of CANCER

Empower the patient – Increase Survival. Empower their support community – Exponentially Increase Survival.

The empowered patient stands uniquely positioned to understand, engage, and ultimately succeed. They hold the power to influence and reshape both science and healthcare, leading to increased survivorship and reducing financial burdens on both private and public levels. This approach offers a common-sense strategy, effectively bridging the gap between the success of early-detectable cancers and the harsh high morbidity rates of cancers only diagnosed at late-stage.

Update: Significant Breakthrough

RealityCheck

HEALTHY PEOPLE GET CANCER TOO; We are all healthy until we are not.

None of us can predict when we might face a cancer diagnosis. Even healthy individuals, including doctors, nurses, and scientists, are not immune. That’s why being well-equipped with knowledge and resources becomes a crucial factor and advantage if we are ever unexpectedly diagnosed with a serious cancer.

Life, Science,and Certainty

There is nothing in life or the science of life that is not vulnerable to being knocked off its precarious pedestal of certainty. The only certainty in life is that there is no certainty, just obstacles and their possibilities. Therefore, the opportunity within life is to see the possibilities within the obstacles and then set about making them our reality.

It is our Choice

When you believe in cancer’s reputation more than you believe in your ability to respond and overcome it – which will triumph?

Changing the Angle of Attack

Shifting Perceptions: Changing the Angle of Attack

To succeed over cancer is to dismantle the diagnosis, to strip it of its reputational packaging, to see it as it really is, not as you fear it is. It is only then that you will be ready to effectively respond.
Follow the Process: The Process methodically breaks the cancer down into small, winnable pieces. It keeps you focused on conquering each step in front of you now – today, removing the disempowering distractions posed by the enormity of the challenge. One step seamlessly follows the next wearing down the cancer’s defences until they are no more – until cancer is no more.

I Have Cancer I Am Going to Die

A crucial distinction: “I Have Cancer” is an objective fact. In contrast, “I Am Going to Die” is very subjective, a borrowed opinion, not a fact. It does not factor in the capacity of a well ‘Equipped and Empowered Patient.’

When diagnosed, it’s critical to see a cancer diagnosis as it is, not as you fear it is; being diagnosed is just a position, not a fate. This clear view unleashes your courage to act on what’s controllable and accept what isn’t. That is when you’re truly ready to effectively respond.

You must quickly move to accept the things you cannot change, have the courage to change the things you can control and change, and possess the wisdom to know the difference. You cannot control that you have cancer, but you can control how you will respond.

Shakespeare said, ‘Nothing is either good or bad, but thinking makes it so.’ Our perception and the stories we tell ourselves determine whether it’s a good story, a bad story, or no story at all.

I recall Theodore Roosevelt’s words, “We must all wear out or rust out.” I choose to wear out. This mindset powered my response when given just weeks to live.

All this is simple, but not easy. It takes practice, persistence, perseverance, and a disciplined focus that comes from taking full responsibility. We as patients must think differently, we must have creative persistence and we must hold our poise and grace – our nerve.

To repeat how I began this page: We must Act with Deliberation, Boldness, and Persistent Creativity: We all have the ‘Inner Will‘ and ‘Freedom‘ to choose these innate attributes at any moment, it is up to us – it is an indisputable right that only we can relinquish. ~ All the best, Steve

My Challenge

Separating the lessons learned from the emotions that encapsulated them has been a significant challenge. Initially, I sought to detach them for clearer communication. Yet, I realized that these emotions are not just carriers, but integral components of the lessons themselves. My challenge now lies in sharing these intertwined experiences in a way that offers tangible benefits

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Warm Regards Steve

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