The Business of Me, a profile of Steve Holmes
The Business of Me, a profile of Steve Holmes

Community and their Villagers + Immmunology-NGS Molecular Profiling -Mutational Match-making, a business profile like no other

A Business profile like no other

Postmodern Villager and Entrepreneur
A Postmodern Villager is someone who embraces the best of the old, and evolves it forward within the best of the now. An evolution of who we were, are, and will become. 

An Entrepreneur is someone who thinks of possibilities beyond the now, then acts on them, immersing and obsessing over them until they find their reality, and more importantly their outward expressions that others will also value.

That pretty much sums up who I am – I have been very fortunate.

Contact Details
Social Handles

Localising globalisation
Re-empowering ‘Localism’ over the irrational Globalised growth grab.
Developing “Smart Localism” models that empower fractured local communities that have suffered the overdose and fallout of globalism. The model’s goal is to centralise and simplify the innate villager resource within each community, re-establishing the value streams at a grassroots level.

Villagers to Village 
The name of our model is Villagers to Village, which highlights the grassroots pathway in regenerating a village. Empowering the Villagers with the process and tools to reclaim their Village. The model creates an online directory and newsflow at its centre, and derives revenues streams from advertising, subscriptions, shop, grants and other online connections.

This is Smart-Localism 
A Postmodern Villager Revival” that empowers the Villagers to reclaim their Village and reignite its local advantages.

Gold Coast 

We have begun on the Gold Coast as this is what we are most familiar with. Destination Main Beach is our first Village candidate as it struggled to re-emerge out of the 2008 business slump. We have begun establishing Destination Surfers Paradise and have had discussions with both Chevron Island and Isle of Capri.

Where to from here =

Destination Villages
DV – Destination Villages is a collective of Villager Communities.
My role is as an investor and creative director in developing this concept.

The Villages
We identify established communities that have lost their mojo and purpose, then insert our Villager to Village model, which essentially re-purposes and re-cultures a community into a vibrant villager styled environment.

The Cancer Tool Kit

A global peer to peer – patient to patient digital tool kit series 

A Highly targeted informational tool kit series containing the distilled collective knowledge, information & wisdom’s from successful Patients and Caregivers. This series places the patient and their tool kit at the center of a community of toolkits designed to synchronize the effort and energy by the many, around what works.

NGS and Molecular Matchmaking
This is still very new, it is cancer busting and it is the tip of a very welcome iceberg in cancer survival – I know this, as I am one of those at the very tip of this very large iceberg. One of the 1% of the 1% to survive an unsurvivable cancer diagnosis.

Through personal experiences and new skill-sets, I have developed a real tangible solution to a significant global problem. The solution meets a need that will save many people from unnecessary cancer deaths.

NGS (Next Generation Sequencing,) Genetic and Genomic Molecular Profiling has opened up new survival opportunities that were not previously possible. The key to this is patient empowerment and application of this.

Realtime Patient to Patient connection and empowerment, transcends boundaries, and bypasses red tape globally.

Patients empowering Patients, delivering today’s lifesaving knowledge today, with particular focus on the “Newly Diagnosed Patients and Caregivers” is directly improving survival outcome opportunities.

  • Created by first business in 1986
  • Live in Main Beach (since 2005) – Hometown is Waikanae NZ.
  • Married to Claire, we have 2 Children
    Zach (30) TSS – Bond – Bentley (Boston)
    Georgia (26)  St Hilda’s – QUT
  • Love Cycling, Running, Walking & Rugby
  • Favourite books  Art of War – Sun Zu, Good to Great – Jim Collins and Future Shock – Alvin Toffler
  • Favourite Music: Love the 80’s remakes, the Postmodern Jazz resurgence, Jefferson Airplane and yes Abba!
  • Favourite Pillars of thought – Happen on life, or life will happen on you.
  • Founded CCA Australasia (Cholangiocarcinoma Australasia)
  • Founded the Immuno-beginner
  • Study the Epigenetic factors of influence, immunology, and the immune response. Primarily my focus is within the CSIR prep exams (Council of Scientific & Industrial Research) to which I have dedicated 2 years of informal study.
  • A great starting point is to read the book “The Gene” which my Oncologist referred to read.
  • Writer, Contributor, and Member of numerous specialist cancer and cancer patient groups across the globe as “the Globally Connected Cancer Patient”
  • Cancer Patient Mentor (globally), Claire is also a mentor to caregivers and she specialises in interpreting and simplifying clinical trials into patient language.

Since the mid 90’s I have had a very fortunate journey in developing and holding New Zealand commercial property, via a family property trust & fund.

Areas of operation

  • Tier One Urban Central:
    Mixed-use retail/hospo. Examples: Monteiths Breweries and other, Restaurants, TAB’s and associated hospo retail.
  • Industrial: City/Urban Mix-Use:
    Village Precincts, Free-Holds, and Free-standing. Government and Private sector.
  • Executive Resi-Spec Developments:
    250 free-standing independent living executive retirement homes. (non-village)

Other Activities

2016 – 2020: I have spent the majority of my time in hospital ICU’s, Surgical Wards, and Treatment facilities. I continue to be a participant on the international Keynote trial 158 until 2023.

2020 has delivered a new inflow of strength, that has allowed me to venture back onto the “business paddock” and re-orientate back into the ebb and flow of people in business. My key challenge is to get my body and mind back into sync, and regain that natural free-flowing confidence prior to cancer.

My focus now is to discover my new relevance and contribution values from the fusion of past skills and experiences with the new.

I included this section primarily because cancer never really leaves you – you can never become “Un-Cancered” and the best strategy is to work with it, and that is no exception when it comes to business – at least that is my belief.

I cycled 200- 400 km’s per week and often ran 30kms – a very enjoyable lifestyle.
Fit and healthy people just do not get cancer, do they!
Hmm – Wrong – think on that again!
No one is immune from cancer reaching out and striking them down – you cannot prepare or eliminate yourself from its reach. The only resources you will have against such a horrid event will be how you choose to respond and act on your response. 

View my CCA Interview the hard facts

In November 2016  I was diagnosed with a terminal cancer called Cholangiocarcinoma (CCA) and given 6 months to live. Like metastatic Pancreatic Cancer, CCA is the most hostile of all cancers. The stats are dire –

  • 1%, chance to survive 2yrs
  • 6.7 months of average life expectancy.
  • CCA begins within the livers bile ducts and connects most of our vital organs, hence the highest morbidity rate of all cancers.
25 hours of Surgeries

In an effort to beat certain death, I undertook 25 hours of surgery, which included a Whipple – the biggest of all multi-organ operations.

Why would I try? because surgery was the only chance I had at survival, even though surgery success is slim, with under 5% surviving more than 5 yrs post-surgery. When it comes to cancer, surgery is the only curative option a patient has – full stop. Chemo and radiation can be effective management tools in some cancers but not when it comes to CCA or Pancreatic.

The operations removed …
  • Stomach – 80%
  • Bile duct – 100%
  • Gallbladder
  • Pancreas – 33%
  • 2 Lymph Nodes
  • Duodenum – 100%
  • Hepatic Artery – 100%

Over the past 3 years, my survival has come down to mere seconds and minutes, and then weeks to days.

  • Immuno Trial: Globally 9 patients globally qualified for keynote trial 158
  • Qualification: To qualify you have to be metastatic and death is imminent – I am the proverbial guinea pig until 2023
  • Making Medical History: I was the only patient to succeed and as a result became the 2nd patient ever to overcome Cholangio from a metastatic setting, via the Immuno agent Keytruda. As of 2020, there are now 3 of us.
Added Note:

My younger brother Graeme (RIP) 2014 – had the same diagnosis. CCA is a non-hereditary, very aggressive and rare cancer – 2 brothers/siblings with the same diagnosis drew attention.

Shout out and share loudly those successes that will help others rise to their victory.

It has been a gigantic 3-year survival battle to overcome a metastatic stage 4 cancer that until recently has been undefeatable.

Learning to live with cancer as an asset

With Cancer, you cannot wander aimlessly for too long, you have to decide on something that gives you purpose from within, if you lie down it will take you, it’s that simple. I found writing everything out of my head was a critical step forward, it was a conduit for me to see myself and all that had happened. I gave me a sense of control and a way of seeing, discovering purpose and purpose gave me momentum and to me, momentum meant living.

You can never become un-cancered,
but you can move forward with the assets of what has been learned.

“Happen on Life or Life Will happen on you,” having said that, life still happened on me, and it did so in a bloody big way.

Up until 2017, I led a fit and healthy lifestyle, which centered around road cycling (my passion.) Typically I rode 300 – 500 km/week and participated in many events across NZ/AU.

Changing direction

I have gained a very unique and intimate knowledge within this environment. I decided to increase my relevance and contribution value to the “Cancer Cure Equation” by studying the science of immunology.

  • CSIR NET: (Council of Scientific and Industrial Research) – Over the past 2 years I have tasked myself in gaining a more accurate understanding of the body’s immune response. I have participated in CSIR prep lectures and panel discussions and other related groups to achieve this. My primary goal is to increase my relevance and contribution value to those who need my help most – “The Newly Diagnosed patient”
  • Primary focus: DNA – RNA – Proteins messaging and microsatellite instabilities, NGS Molecular Profiling, specifically Immune Check Point and Growth Factor Blockades.
  • My area of focus is GI (Gastro-Intestinal) Adenocarcinoma Mutations,
  • I contribute this knowledge back to “the Globally Connected Patient” – a collective patient and caregiver knowledge hub who gift forward their knowledge, experiences and wisdom to empower the “Newly Diagnosed Patient and Caregiver”

The Immuno breakthrough was thanks to Nobel Prize Winner Dr. Jim Allison’s CTLA-4 Checkpoint pathway breakthrough became the biggest medical event since the discovery of penicillin – the greatest breakthrough in modern medical history, and the first time the word cure and cancer has been used in the same sentence.
Nobel prize -Medicine-Allison


These are the people that saved my life and a family.

  • Dr. Jim Allison (Texas USA),
  • Dr. Matthew Burge (Brisbane Australia), and
  • Dr. Tom Snow (Gold Coast Australia)
Lemons to Lemonade if you are open to this idea?

Becoming such a rare stat in the cancer world thrust me in a new direction where I have met and spent time with International Hollywood Actors and Televisions Personalities, US Senators Aids, along with the most influential science and cancer researchers in the world. Last year I was hosted, cycled with and pampered by Tour de France Cyclists over 1 week of the Tour Down Under. I have formed some very special and amazing friendships, that simply would never have happened if not for cancer. Pretty incredible (almost unreal) stuff for a small-town Kiwi kid. As for the lemonade, I am still working on my unique brand of lemonade, from the lemons I have been dealt.

A collection of my thinking habits that evolved throughout my successes and challenges, and as it transpired I believe they became the foundational thinking, that saved my life.

Anything & Everything is possible.
Anything and everything is possible providing I remain willing and open to it. Typically the opportunity lays just beyond your current vision – remaining willing and open will expand this.

Trojan horses and Florence Nightingales 
Family and friends can be the most dangerous gift bearers with their well-intentioned, misguided advice, that you would otherwise not allow into your head.

Reality Wars 
I do not allow the uninvited realities to invade my space. This is not easy and it does require discipline, but I find that when I am busy building and refining my own reality, by default this leaves no room for the uninvited. An idle aimless mind can easily become the victim to the avalanches of other peoples realities where all seems lost.

My reality is my reality and your reality is yours.
This understanding has allowed me to find poise and see what others cannot in times of chaos or disruption, but be warned it can and will upset many.

Rise and Rise until Lambs become Lions
Entrepreneurial and business efforts will always take the hits, more often than not the only /best plan, is to make that next step and the one beyond that, no matter how small or insignificant it may seem in that moment – Momentum, any momentum is good.

Habits in Surviving and Striving Well
Over the years I developed out of necessity a template of how I approach things. These 2 templates have helped me develop how I responded and act on problems and opportunities. I live by this every day.

Habits of Surviving Well
My survival habits are as important as my success habits,

  1. Acceptance: Acceptance of the current reality is everything, it helps me become open and aware. Acceptance helps me reset and regain some type of control -it helps me find momentum and move forward.
  2. Willingness: Unconditional Willingness is a toughie, but it keeps me open to the possibilities.
  3. Chapters of Me: I like to write myself out of a bad story, dumping all the bad stuff out of my head, so I can see it for what it was. This free’s my mind to begin writing myself into a better story, and a better reality.

Habits of Striving well
As much as I needed Survival skills, I also need habits to thrive and accelerate – these are my constant companions that keep me on direction –

  1. Be a little unrealistic often: This always feeds my dreams, builds vision, and stimulates my aspirations. Mostly it gives my dreams the space to breathe and bathe in their own realities, free from the oppressive disapprovals others. It tends to reveal and crystalise ‘One important thing,’ that I could see before.
  2. Do that one thing, then
  3. Be remarkable @ it, and
  4. Be Resourceful with it.
  5. Add Value to it or don’t do it
  6. Surround it with talented people of character, that share the vision and can make it a reality.

Thoughts are Things 
We all have an innate freedom on how we think and choose, until we have drawn our last breath. I am certain many great victories have come from this understanding – My own experience underpins such belief.

I am adding new thought pillars.

I think Localism and Phygitalisation are fast becoming the new frontiers.
Globalisation has become what free indiscriminate sex was to “Aids.” We now have to navigate and evolve into a brand new frontier of connectedness and trust, a new wave of inconvenience, innovation, and solutions has begun.

A Business profile like no other

Pursuing Perfection is a great thing –
It has flushed out my potentials and kept me on direction – 

Cheers Steve

A Business profile like no other

Pursuing Perfection is a great thing –
It has flushed out my potentials and kept me on direction – 

Cheers Steve
A Business profile like no other

A Business profile like no other
The Business of Me, a profile of Steve Holmes