Smart Localism, Immmunology, Mutational Match-making, and NGS Genomic Profiling, a brave new world of opportuniies

Please say gidday –

Ph.+61 41 515 3522

Personal and other activities 

steve@steveholmes.net.au

Destination Main Beach

steve@destinationmainbeach.com.au

Social Handles
Destination Main Beach

Immuno-beginner

The Cancer Toolkit Series

View my ‘Cancer’, ‘Personal’ & ‘Business’ Bio’s in Further Details bottom of this page.

Business profile and insghts

Thanks for dropping by.

I began my working life in pursuit of golfing glory via our local ProAm circuit as a plus 2 golfer. The romance of stardom on the 18th was very compelling at 17 years of age, however, sleeping in the back seat of my old Vauxhall Viva parked in a cornfield or paddock quickly shifted my aspirations. With a Bob Jones property book, and Napoleon Hill’s “Think and Grow Rich” in the back seat, I quickly switched aspirations as I learned of the word entrepreneur, and all the nicer things that came with it. Since then I have built, acquired, and sold several businesses along the way.

Evolving with the opportunity

In recent years I have added technology skills to my toolkit in order to remain relevant in a fast-changing business landscape. Obtaining a competency in technology is very similar to obtaining a drivers license – you gain control,  increase your range of opportunity and participation.

Current Activities.

I am currently investing my time and money into two areas.

Smart Localism 

Technology

Relocalising our Community identity, resources, and people. In simple terms this means technology solutions that re-empower the local over global.
A paddock to plate styled purpose, built on the local foundations of shared values, visions, and aspirations.

A Village for the Villagers, by the villagers.

Unique and original platform designs that re-centralise and simplify, fractured, and disenfranchised local community ecosystems.

The key pillars.
  1. Centralise:  Centralising and simplifying the community’s assets and resources, galvanises the Village identity, relevance.
  2. Chatter: Build the chatter and Villager Vibe around this centre
  3. People become Villagers: Surround the Village platform with people of character and talent, ‘Villagers’ who collectively share the same values, purpose, and aspirations. People who can transform it all to the next level.
Smart Localism leverages the attributes of globalisation to the benefit of the local grassroots Villager and their Values, visions and aspirations.
Model /Platform

Current View Destination Main Beach

Main Beach has been our beta and template community, and we have recently begun scoping out Destination Surfers Paradise, Destination Isle of Capri, and Destination Chevron Island.

Villager to Village technology platforms, provide a foundation and visibility for community voice and identity. Happy Villagers build a healthy community.

Immunology

Mutational Matchmaking 

Next-Gen Sequencing and Genomoic / Molecular Profiling.
Peer to peer technology that connects cancer patients by their exact mutation. An analogy could be – a ‘Tinder styled’ service for introducing and connecting people via their exact mutational type or grouping. This is currently in Beta testing via the USA and will be available globally.

The future is now

Cancer has shifted its pursuit of a cure to treating the “Mutation” that drives the cell’s cancer growth – as opposed to identifying and treating by traditional cancers generic type – for example, Breast Cancer has multiple subsets that are defined by the variety of mutations that cause the cancer growth.

Matchmaking successful science to the newly diagnosed is leading to a cure.

NGS and Immunotherapy are game-changers – Next Generation Sequencing spotlights and road maps the exact mutation(s) driving a diseased cell’s cancer growth. This spotlight provides a roadmap and a pathway to target, subdue and or eliminate these mutational drivers. NGS has created visibility where historically there has been none. This has now lead to the development of multiple new breakthrough immunotherapy agents.

2015 -A modern medical miracle not witnessed since the discovery of penicillin.
Prof. James Allison discovered the CTLA-4 and PD-1 Checkpoint Pathways, The first ever cancer cure outside of successful surgery.
The world’s biggest killers –
  1. Lack of today’s current scientific and medical success information, reaching the newly diagnosed cancer patient today.
  2. Newly diagnosed patients assuming that all Oncologists are equal and current.
  3. Not being Genomically Profiled for mutations, which are then matched to current immunotherapy treatment options..
The Cancer Toolkit Series

The Cancer Toolkit is a global peer to peer – patient to patient digital tool kit series for the newly diagnosed patient and their support community. A highly targeted family of informational tool kit, with the patient’s toolkit of at its centre. The CTK series connects guides and connects the Caregiver, Mum and Dads, children, friends, work colleagues, and more. Designed to synchronise the whole effort, thus providing the patient with the best possible outcomes.

Further Details

Since the mid 90’s I have had a very fortunate journey in developing and holding New Zealand commercial property, via a family property trust & fund.

Areas of operation

  • Tier One Urban Central:
    Mixed-use retail/hospo. Examples: Monteiths Breweries and other, Restaurants, TAB’s and associated hospo retail.
  • Industrial: City/Urban Mix-Use:
    Village Precincts, Free-Holds, and Free-standing. Government and Private sector.
  • Executive Resi-Spec Developments:
    250 free-standing independent living executive retirement homes. (non-village)

Other Activities

2016 – 2020: I have spent the majority of my time in hospital ICU’s, Surgical Wards, and Treatment facilities. I continue to be a participant on the international Keynote trial 158 until 2023.

2020 has delivered a new inflow of strength, that has allowed me to venture back onto the “business paddock” and re-orientate back into the ebb and flow of people in business. My key challenge is to get my body and mind back into sync, and regain that natural free-flowing confidence prior to cancer.

My focus now is to discover my new relevance and contribution values from the fusion of past skills and experiences with the new.

  • Created by first business in 1986
  • Live in Main Beach (since 2005) – Hometown is Waikanae NZ.
  • Married to Claire, we have 2 Children
    Zach (30) TSS – Bond – Bentley (Boston)
    Georgia (26)  St Hilda’s – QUT
  • Love Cycling, Running, Walking & Rugby
  • Favourite books  Art of War – Sun Zu, Good to Great – Jim Collins and Future Shock – Alvin Toffler
  • Favourite Music: Love the 80’s remakes, the Postmodern Jazz resurgence, Jefferson Airplane and yes Abba!
  • Favourite Pillars of thought – Happen on life, or life will happen on you.
Also
  • Founded CCA Australasia (Cholangiocarcinoma Australasia)
  • Founded the Immuno-beginner
  • Study the Epigenetic factors of influence, immunology, and the immune response. Primarily my focus is within the CSIR prep exams (Council of Scientific & Industrial Research) to which I have dedicated 2 years of informal study.
  • A great starting point is to read the book “The Gene” which my Oncologist referred to read.
  • Writer, Contributor, and Member of numerous specialist cancer and cancer patient groups across the globe as “the Globally Connected Cancer Patient”
  • Cancer Patient Mentor (globally), Claire is also a mentor to caregivers and she specialises in interpreting and simplifying clinical trials into patient language.

I included this section primarily because cancer never really leaves you, you can never magically become “Un-Cancered” but you can take control and get alongside it. Mirroring that age-old saying of “Keeping your friends close and your enemies even closer”

Prior to being diagnosed with a very terminal and unsurvivable cancer, I was preverbally fit and healthy, cycling 200 – 400 km’s per week – not the typical cancer candidate – and my family lineage was long life healthy spans.

No one is immune from cancer reaching out and striking them down,  and you cannot prepare or eliminate yourself from its reach. The only resources you will have against such a horrid event will be how you choose to respond and act on your response. Thoughts in and thinking actions out – that’s all you will have to defend yourself. 

View my CCA Interview the hard facts

In November 2016  I was diagnosed with a terminal cancer called Cholangiocarcinoma (CCA) and given 6 months to live. Like metastatic Pancreatic Cancer, CCA is the most hostile of all cancers. The stats are dire –

  • 1%, chance to survive 2yrs
  • 6.7 months of average life expectancy.
  • CCA begins within the livers bile ducts and connects most of our vital organs, hence the highest morbidity rate of all cancers.
25 hours of Surgeries

In an effort to beat certain death, I undertook 25 hours of surgery, which included a Whipple – the biggest of all multi-organ operations.

Why would I try? because surgery was the only chance I had at survival, even though surgery success is slim, with under 5% surviving more than 5 yrs post-surgery. When it comes to cancer, surgery is the only curative option a patient has – full stop. Chemo and radiation can be effective management tools in some cancers but not when it comes to CCA or Pancreatic.

The operations removed …
  • Stomach – 80%
  • Bile duct – 100%
  • Gallbladder
  • Pancreas – 33%
  • 2 Lymph Nodes
  • Duodenum – 100%
  • Hepatic Artery – 100%

Over the past 3 years, my survival has come down to mere seconds and minutes, and then weeks to days.

  • Immuno Trial: Globally 9 patients globally qualified for keynote trial 158
  • Qualification: To qualify you have to be metastatic and death is imminent – I am the proverbial guinea pig until 2023
  • Making Medical History: I was the only patient to succeed and as a result became the 2nd patient ever to overcome Cholangio from a metastatic setting, via the Immuno agent Keytruda. As of 2020, there are now 3 of us.
Added Note:

My younger brother Graeme (RIP) 2014 – had the same diagnosis. CCA is a non-hereditary, very aggressive and rare cancer – 2 brothers/siblings with the same diagnosis drew attention.

Shout out and share loudly those successes that will help others rise to their victory.

It has been a gigantic 3-year survival battle to overcome a metastatic stage 4 cancer that until recently has been undefeatable.

Learning to live with cancer as an asset

With Cancer, you cannot wander aimlessly for too long, you have to decide on something that gives you purpose from within, if you lie down it will take you, it’s that simple. I found writing everything out of my head was a critical step forward, it was a conduit for me to see myself and all that had happened. I gave me a sense of control and a way of seeing, discovering purpose and purpose gave me momentum and to me, momentum meant living.

You can never become un-cancered,
but you can move forward with the assets of what has been learned.

“Happen on Life or Life Will happen on you,” having said that, life still happened on me, and it did so in a bloody big way.

Up until 2017, I led a fit and healthy lifestyle, which centered around road cycling (my passion.) Typically I rode 300 – 500 km/week and participated in many events across NZ/AU.

Changing direction

I have gained a very unique and intimate knowledge within this environment. I decided to increase my relevance and contribution value to the “Cancer Cure Equation” by studying the science of immunology.

  • CSIR NET: (Council of Scientific and Industrial Research) – Over the past 2 years I have tasked myself in gaining a more accurate understanding of the body’s immune response. I have participated in CSIR prep lectures and panel discussions and other related groups to achieve this. My primary goal is to increase my relevance and contribution value to those who need my help most – “The Newly Diagnosed patient”
  • Primary focus: DNA – RNA – Proteins messaging and microsatellite instabilities, NGS Molecular Profiling, specifically Immune Check Point and Growth Factor Blockades.
  • My area of focus is GI (Gastro-Intestinal) Adenocarcinoma Mutations,
  • I contribute this knowledge back to “the Globally Connected Patient” – a collective patient and caregiver knowledge hub who gift forward their knowledge, experiences and wisdom to empower the “Newly Diagnosed Patient and Caregiver”

The Immuno breakthrough was thanks to Nobel Prize Winner Dr. Jim Allison’s CTLA-4 Checkpoint pathway breakthrough became the biggest medical event since the discovery of penicillin – the greatest breakthrough in modern medical history, and the first time the word cure and cancer has been used in the same sentence.
Nobel prize -Medicine-Allison

Cancer

These are the people that saved my life and a family.

  • Dr. Jim Allison (Texas USA),
  • Dr. Matthew Burge (Brisbane Australia), and
  • Dr. Tom Snow (Gold Coast Australia)
Lemons to Lemonade if you are open to this idea?

Becoming such a rare stat in the cancer world thrust me in a new direction where I have met and spent time with International Hollywood Actors and Televisions Personalities, US Senators Aids, along with the most influential science and cancer researchers in the world. Last year I was hosted, cycled with and pampered by Tour de France Cyclists over 1 week of the Tour Down Under. I have formed some very special and amazing friendships, that simply would never have happened if not for cancer. Pretty incredible (almost unreal) stuff for a small-town Kiwi kid. As for the lemonade, I am still working on my unique brand of lemonade, from the lemons I have been dealt.

This may seem a little odd to be included in a business profile, but I feel that it is very important to share my primary habits of thought. They have evolved over the years through many successes and challenges in both business and life. As it transpired I believe they became the foundational thinking, that saved my life.

Anything & Everything is possible.
I have learned that “Anything and Everything” is possible, whilst I remain open to it. I leave the door open and the lights on, so that the opportunities just beyond my conscious vision, can find their way to me.

Trojan horses and Florence Nightingales 
Family and friends can be the most dangerous gift bearers with their well-intentioned, misguided advice, that you would otherwise not allow into your head.

Reality Wars 
I do not allow the uninvited realities to invade my space. This is not easy and it does require discipline, but I find that when I am busy building and refining my own reality, by default this leaves no room for the uninvited. An idle aimless mind can easily become the victim to the avalanches of other peoples realities where all seems lost.

My reality is my reality and your reality is yours.
This understanding has allowed me to find poise and see what others cannot in times of chaos or disruption, but be warned it can and will upset many.

Rise and Rise until Lambs become Lions
Entrepreneurial and business efforts will always take the hits, more often than not the only /best plan, is to make that next step and the one beyond that, no matter how small or insignificant it may seem in that moment – Momentum, any momentum is good.

Habits in Surviving and Striving Well
Over the years I developed out of necessity a template of how I approach things. These 2 templates have helped me develop how I responded and act on problems and opportunities. I live by this every day.

Habits of Surviving Well
My survival habits are as important as my success habits,

  1. Acceptance: Acceptance of the current reality is everything, it helps me become open and aware. Acceptance helps me reset and regain some type of control -it helps me find momentum and move forward.
  2. Willingness: Unconditional Willingness is a toughie, but it keeps me open to the possibilities.
  3. Chapters of Me: I like to write myself out of a bad story, dumping all the bad stuff out of my head, so I can see it for what it was. This free’s my mind to begin writing myself into a better story, and a better reality.

Habits of Striving well
As much as I needed Survival skills, I also need habits to thrive and accelerate – these are my constant companions that keep me on direction –

  1. Be a little unrealistic often: This always feeds my dreams, builds vision, and stimulates my aspirations. Mostly it gives my dreams the space to breathe and bathe in their own realities, free from the oppressive disapprovals others. It tends to reveal and crystalise ‘One important thing,’ that I could see before.
  2. Do that one thing, then
  3. Be remarkable @ it, and
  4. Be Resourceful with it.
  5. Add Value to it or don’t do it
  6. Surround it with talented people of character, that share the vision and can make it a reality.

Thoughts are Things 
We all have an innate freedom on how we think and choose, until we have drawn our last breath. I am certain many great victories have come from this understanding – My own experience underpins such belief.

NEW:
I am adding new thought pillars.

I think Localism and Phygitalisation are fast becoming the new frontiers.
Globalisation has become what free indiscriminate sex was to “Aids.” We now have to navigate and evolve into a brand new frontier of connectedness and trust, a new wave of inconvenience, innovation, and solutions has begun.